Daniel Sinclair @_DanielSinclair Building for young people. Not reading @danielsunread. Lurking behind likes and thinking about social media, communication, & China. May. 24, 2019 1 min read

Very excited to see the gene therapy flood gates opening; this is now the 2nd therapy approved by the FDA, and many more are on the way.  https://www.statnews.com/2019/05/24/hold-novartis-zolgensma-approval/ 

On a 30 to 70 year horizon, the gene therapy market feels fairly ephemeral. Germline edits and IVF sequencing will be drastically more cost-effective as primary treatment. As our genome understanding increases, the gene therapy market will ultimately peak and then rapidly decline

Societal pressure & norm will ultimately push towards germline edits. But there's other factors: fertility globally is plummeting, and we may have no choice. "[Concentration] declined more than 50% from 1973 to 2011... total counts were down by almost 60%"  https://www.theatlantic.com/family/archive/2018/10/sperm-counts-continue-to-fall/572794/ 


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