Note: This thread is related to #Coronavirus #COVID19

Follow the World Health Organization's instructions to reduce your risk of infection:

1/ Frequently clean hands by using alcohol-based hand rub or soap and water.

2/ When coughing and sneezing cover mouth and nose with flexed elbow or tissue - throw issue away immediately and wash hands.

3/ Avoid close contact with anyone that has fever and cough.

Nicholas A. Christakis+ Your Authors @NAChristakis Sterling Professor of Social & Natural Science at Yale. Physician. Author of Blueprint: The Evolutionary Origins of a Good Society. Luckily wed @ErikaChristakis Apr. 06, 2020 1 min read + Your Authors

I was going to write about whether there is any good evidence for chloroquine in the treatment of COVID19. There is none yet, and it might be *harmful*. This is why we need RCTs. My thread would not have been better than this:  https://annals.org/aim/fullarticle/2764199/use-hydroxychloroquine-chloroquine-during-covid-19-pandemic-what-every-clinician  via @JYazdanyMD @AnnalsofIM

More sober-minded assessment of the possible efficacy of chloroquine for COVID19 via @Dereklowe  https://blogs.sciencemag.org/pipeline/archives/2020/04/06/hydroxychloroquine-update-for-april-6  We could easily harm people by using this drug on a wide scale.

This behavior of high-profile recommendation of chloroquine, without adequate evidence, is irresponsible and may cost lives without saving any.  https://www.politico.com/amp/news/2020/04/06/trump-drug-coronavirus-hydroxychloroquine-170543  Unlike the fictitious homeopathic cure Forsythia, this is being hawked by the president.

Wuhan doctors treating coronavirus patients with chloroquine for the past few months say there's no clear evidence the drug works against COVID19, raising questions about a remedy some have touted as a potential cure. rel="nofollow"> https://www.wsj.com/articles/chinese-doctors-at-coronavirus-hub-cast-doubt-on-chloroquine-as-cure-11586448660?redirect=amp#click= class='tco-ellipsis'> … Via
@JNBPage @WSJ

Small Brazilian RCT of chloroquine for COVID19 (N=81) stopped early because treatment group developed concerning cardiac dysrhythmias.  https://www.medrxiv.org/content/10.1101/2020.04.07.20056424v1 

Observational study of US patients in VA system finds no benefit to chloroquine. N=368 patients were evaluated (HC, n=97; HC+AZ, n=113; no HC, n=158). Rates of death in the HC, HC+AZ, and no HC groups were 27.8%, 22.1%, 11.4%, respectively.  https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1.full.pdf 

FDA weighs in on use of chloroquine in COVID19. They are sensible. And unamused. rel="nofollow"> https://www.nytimes.com/2020/04/24/health/fda-hydroxychloroquine-coronavirus.html#click= class='tco-ellipsis'> 

Another small cohort study (N=90) suggests chloroquine does more harm than good in COVID19 cases. via @JAMACardio  https://jamanetwork.com/journals/jamacardiology/fullarticle/2765631 

This tweet about this topic, and the President’s reckless statement and Fox’s absurd and dangerous pandering to their crowd, was too good not to add to this thread.

Large international observational cohort study of 96,032 patients, just out in @TheLancet, shows no benefit (and possible cardiac risk) of chloroquine in treatment of COVID19, even when used early in the course of hospitalization.


You can follow @NAChristakis.



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