Note: This thread is related to #Coronavirus #COVID19

Follow the World Health Organization's instructions to reduce your risk of infection:

1/ Frequently clean hands by using alcohol-based hand rub or soap and water.

2/ When coughing and sneezing cover mouth and nose with flexed elbow or tissue - throw issue away immediately and wash hands.

3/ Avoid close contact with anyone that has fever and cough.

Natalie E. Dean, PhD+ Your Authors @nataliexdean Assistant Professor of Biostatistics at @UF specializing in emerging infectious diseases and vaccine study design. @HarvardBiostats PhD. Tweets my own. Jun. 08, 2020 1 min read + Your Authors

I was on a panel recently opposite a pharma exec. He suggested a pathway for approving vaccines based on immunogenicity data (not randomized field or challenge trials). The goal was to get vaccines to the American people sooner. I pushed back immediately. We can’t cut corners.

A parallel would be approving HCQ based on any of the “promising” but uncontrolled studies that came out in April. It’s just not enough information.

There are exceptional circumstances where vaccines are approved by "alternative pathways" (animal rule, etc). These pathways are typically only considered where a randomized field trial is not possible. Rabies vaccine is a good example.

For COVID, not only is a randomized field trial possible, it could be done quickly if placed in areas with high transmission. And like the Ebola ring vaccination trial, the trial is part of the outbreak response. Many thousands vaccinated to demonstrate that the vaccine works.

Science is already working at lightning speed to find vaccines (plural) that we are confident are safe and effective. In the mean time, we need to build up our other tools (testing, tracing, sustainable behavior changes) so that we can live safely.

You can follow @nataliexdean.


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