Ashish K. Jha+ Your Authors @ashishkjha Physician, researcher, and advocate for the notion that an ounce of data is worth a thousand pounds of opinion. Director @harvardgh. Soon, Dean @Brown_SPH Jul. 28, 2020 1 min read + Your Authors

New study out on the mRNA-1273 vaccine in @NEJM and its more good news.

Its a study in non-human primates -- a challenge study where primates were vaccinated, then challenged with the virus.

 https://www.nejm.org/doi/full/10.1056/NEJMoa2024671 

So what did they find?

As I said, good news.

Short thread

24 rhesus macques were innoculated with one of two doses of the vaccine

They all developed (especially at the higher doses) neutralizing antibodies

And developed t-cell responses.

More robust in the higher dose

But there's more!

2/3

When subsequently challenged by SARS-CoV2, small number of macques had any detectable virus

None developed severe illness

More evidence that m-RNA vaccines will likely work

We obviously still need to await phase 3 trials

But I'm optimistic we will have a vaccine in 2021

Fin


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