Note: This thread is related to #Coronavirus #COVID19

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Alasdair Munro+ Your Authors @apsmunro Paediatric Registrar | Clinical Research Fellow Paediatric Infectious diseases @southamptonCRF | @DFTBubbles #COVID19 evidence review lead | Husband and dad Aug. 03, 2020 2 min read + Your Authors

OK I'm busy trying to catch up with what I've missed on #COVID19 in children, which looks like a lot!

People seem to be making a big deal out of some new papers, but frankly there's not a huge amount of new information here - quick run down


This paper examines a big outbreak at an overnight camp in Georgia (USA) during a period of high community transmission

Lots of kids infected, including young children


Over such a brief period of time, likely kids didn't actually have time to transmit to each other. Mainly got infected by staff

Good break down here by @DiseaseEcology (although I disagree with the take on household transmission studies!)


We've known for some time children can get infected in mass spreading events, albeit has mostly been demonstrated in older children (see study from France)

Attack rate is pretty high though!


Next an outbreak in a high school in Israel

We cannot tell direction of transmission, but to me this looks like too many cases too fast to all be spread between children; I imagine multiple sources of entry

Secondary schools do seem higher risk


Next a surprising study showing higher viral loads in younger children than adults?! At odds with previous studies showing similar, or lower VL


See here (L'Huillier) 

Here (Jones) 

Here (Kawasuji) 

Confused? Me too.


We already known children have transmissible virus, so this isn't new information

It's nice that they targeted ONLY symptomatic individuals, so at least we have a consistent denominator

Shame we still don't know how many children are asymptomatic...


Next a study suggesting school closures in the USA may have prevented infections/deaths

Sadly it's impossible to tell from these studies the true effect as school closures are never adopted in isolation

Not sure it's helpful


On which note, this study from Japan on the same topic found it made no difference

Not sure we've gotten any further


Finally, 2 excellent pre-print review articles to highlight

The first by @mugecevik @mlipsitch and @EdwardGoldste16 (a veritable A team of #COVID19) on age and transmission 


The next also by @mugecevik et al. on viral dynamics of #COVID19

Includes interesting findings on duration of viral shedding according to age (although kids data poor, might explain apparent reduced infectivity of children despite similar VL?)


Quick whistle stop tour there - hope to come back to some of these when (or if!) I have more time!

Hoping to get the @DFTBubbles #COVID19 in children review up to date soon too! 


You can follow @apsmunro.


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